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Inflammatory markers and antichlamydial antibodies in patients with metabolic syndrome

Rosecler Riethmuller Franco1, Luiz Carlos Bodanese, Giuseppe Repetto

  • 1Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil. rosecler.franco@unijui.edu.br

Arquivos Brasileiros De Cardiologia
|November 27, 2010
PubMed

Insights

Metabolic syndrome patients with cardiovascular events showed higher levels of inflammatory markers like IL-6 and TNF-α. However, anti-chlamydial antibodies did not significantly differ between groups with and without cardiovascular events.

Area of Science:

  • Cardiology
  • Immunology
  • Metabolic Disorders

Background:

  • Metabolic syndrome (MS) is a significant risk factor for cardiovascular events.
  • Inflammatory markers and anti-chlamydial antibodies are implicated in atherosclerosis and cardiovascular disease progression.

Purpose of the Study:

  • To assess inflammatory markers (IL-6, TNF-α) and anti-Chlamydia pneumoniae antibodies in metabolic syndrome patients.
  • To compare these markers in patients with and without cardiovascular events.

Main Methods:

  • Cross-sectional study of 147 individuals with metabolic syndrome.
  • 100 patients without cardiovascular events, 47 with events (including acute myocardial infarction and cerebrovascular accident).
  • Diagnosis of MS based on NCEP-ATP III criteria.

Main Results:

  • Elevated levels of IL-6 and TNF-α observed in patients with cardiovascular events (p=0.001).
  • Higher IgG anti-C. pneumoniae antibodies in MS patients without events, and IgA in those with events.
  • No significant difference in anti-chlamydial antibodies for acute myocardial infarction and stroke patients compared to controls.

Conclusions:

  • Inflammatory markers IL-6 and TNF-α are significantly elevated in metabolic syndrome patients experiencing acute myocardial infarction and stroke.
  • Anti-chlamydial antibodies did not show a significant difference between metabolic syndrome patients with and without cardiovascular events.
Abstract

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