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Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Somatic to iPS Cell Reprogramming

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...

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Related Experiment Video

Updated: Jun 6, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

Published on: February 2, 2024

Induced pluripotent cancer cells: progress and application.

Chun Sun¹, Yin Kun Liu

¹Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China.

Journal of Cancer Research and Clinical Oncology

|November 27, 2010

Summary

This summary is machine-generated.

Generating induced pluripotent cancer (iPC) cells from cancer cells offers a powerful tool for studying cancer development and drug screening. Overcoming reprogramming challenges is key to unlocking the potential of iPC cells in cancer research.

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Last Updated: Jun 6, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

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Area of Science:

Stem cell biology
Cancer research
Epigenetics

Background:

Induced pluripotent stem (iPS) cells are reprogrammed non-pluripotent cells.
Cancer-specific iPS cells (iPC cells) are valuable for modeling oncogenesis and drug screening.
Reprogramming cancer cells into iPC cells is challenging due to their unique genetic and epigenetic profiles.

Purpose of the Study:

To review the experimental challenges in generating iPC cells.
To discuss the potential applications of iPC cells in cancer research.
To provide insights into overcoming reprogramming hurdles for iPC cell generation.

Main Methods:

Literature review of iPS cell reprogramming techniques.
Analysis of genetic and epigenetic factors influencing cancer cell reprogramming.
Discussion of potential strategies to enhance iPC cell generation efficiency.

Main Results:

Cancer cells present unique reprogramming barriers compared to normal cells.
Specific transcription factors are crucial for inducing pluripotency.
The review highlights experimental difficulties and potential solutions for iPC cell generation.

Conclusions:

iPC cells offer a promising platform for cancer modeling and drug discovery.
Further research is needed to optimize the generation of iPC cells.
Addressing the reprogramming challenges will advance the utility of iPC cells in oncology.