Related Experiment Video
Updated: Jun 6, 2026
08:40
Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
Published on: August 23, 2022
[Changes in the bacterial spectrum in severe burn wounds]
B Lipový1, H Rihová, M Hanslianová
1Klinika popálenin a rekonstrukcní chirurgie FN Brno. b.lipovy@seznam.cz
Summary
Gram negative bacteria in burn wounds increase during hospitalization, though they do not become predominant even after 20 days. This study tracked bacterial strains in burn patients over time.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Burn Care
Context:
- Hospital-acquired infections pose a significant threat to burn patients.
- Understanding the dynamics of bacterial colonization is crucial for effective treatment.
- Gram-negative bacteria are common and often resistant pathogens in burn wound infections.
Purpose:
- To establish the timeline for the increase of Gram-negative bacterial strains in burn wounds during a hospital stay.
- To analyze the prevalence of Gram-negative vs. Gram-positive bacteria in burn wound infections over time.
Summary:
- A retrospective study analyzed 777 bacterial strains from 85 burn patients (≥15% TBSA burned, ≥1 month stay).
- Specimens were collected on days 2, 6, 10, 14, and 20 post-admission.
- While Gram-positive bacteria were more prevalent overall (64.6%), Gram-negative strains (35.4%) showed an increasing trend during hospitalization, with Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter calcoaceticus-baumannii complex being common.
Impact:
- Provides critical data on the temporal emergence of Gram-negative bacteria in burn wounds.
- Informs clinical practices for infection surveillance and management in burn units.
- Highlights the need for continued monitoring of bacterial dynamics throughout prolonged hospitalizations.
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