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Updated: Jun 6, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
UVA/riboflavin crosslinking as treatment for corneal melting
N Al-Sabai1, C Koppen, M J Tassignon
1Department of Ophthalmology, Antwerp University Hospital. alsabay2000@msn.com
Purpose:
To demonstrate that UVA/riboflavin crosslinking (CXL) can stop corneal melting in therapy resistant infectious corneal ulceration.
Methods:
We will present a case report on a 70-year-old female patient referred for severe infectious ulcerative keratitis caused by Pseudomonas aeruginosa. After intensive treatment with fortified antibiotics, corneal melting developed. CXL was performed to avoid imminent corneal perforation.
Results:
The CXL treatment was successful: the corneal melting was stopped and the lesion cicatrized, thereby avoiding emergency keratoplasty.
Conclusion:
This case report highlights that CXL may be a valuable addition to our therapeutic armamentarium in the treatment of corneal melts.
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