Symposium report: the Waters Bioanalysis World Tour.

Area of Science:

• Pharmaceutical Analysis
• Bioanalysis
• Analytical Chemistry

Background:

• A symposium focused on advancing bioanalytical techniques was held at the Applied Pharmaceutical Analysis meeting.
• The event aimed to address challenges in pharmaceutical analysis, emphasizing increased sensitivity and data quality.

Framework:

• The symposium featured expert presentations on critical aspects of modern bioanalysis.
• Discussions centered on improving sample preparation, chromatographic separation, and mass spectrometric detection.

Implementation:

• Sample extraction plates for phospholipid depletion were presented to improve sample purity.
• Two-dimensional Ultra-Performance Liquid Chromatography (2D UPLC) was discussed for enhanced selectivity in UPLC-MS/MS.
• Microfluidic chip-based columns and novel mass spectrometer sources were explored for increased assay sensitivity in dried blood spot analysis.

Implications:

• Advancements in these areas are crucial for drug discovery and development.
• Improved sensitivity and data quality in bioanalysis lead to more reliable and efficient pharmaceutical research.
• The presented technologies offer potential for more sensitive and selective quantitative bioanalysis.