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Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Changes in the Appendicular Skeleton with Age

Changes in the Appendicular Skeleton with Age

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The Effect of Aging on Tissues

The Effect of Aging on Tissues

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Osteoclasts in Bone Remodeling

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Related Experiment Video

Updated: Jun 6, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Microarchitectural adaptations in aging and osteoarthrotic subchondral bone issues.

¹Department of Orthopaedics, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense C, Denmark. ming.ding@ouh.regionsyddanmark.dk

Acta Orthopaedica. Supplementum

|November 30, 2010

Summary

Human bone adapts to mechanical stress, but bone loss and degeneration occur with aging and osteoarthritis (OA). This study investigated age- and OA-related changes in bone microarchitecture and quality.

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Area of Science:

Orthopedics
Biomedical Engineering
Gerontology

Background:

The human skeleton adapts its microarchitecture to mechanical loading through bone modeling and remodeling.
Peak bone mass is reached in early adulthood, followed by age-related bone loss and microarchitectural deterioration, increasing fracture risk.
Aging and osteoarthritis (OA) lead to bone loss and joint degeneration, posing significant healthcare challenges.

Purpose of the Study:

To investigate age-related and osteoarthrosis (OA)-related changes in the 3-D microarchitecture, mechanical properties, and tissue quality of subchondral bone.
To assess aging and early OA-related changes in human cancellous bone.
To study spontaneous OA development, hyaluronan effects, and bisphosphonate treatment in OA guinea pig models.

Main Methods:

Analysis of human subchondral cancellous bone properties in aging and early OA.
Development and study of OA guinea pig models to assess spontaneous OA, hyaluronan treatment, and bisphosphonate effects on bone remodeling and OA progression.

Main Results:

Age-related and OA-related changes in subchondral bone microarchitecture and tissue quality were assessed in human subjects.
Guinea pig models provided insights into spontaneous OA development and the effects of hyaluronan and bisphosphonates on OA subchondral bone.

Conclusions:

Understanding age-related and OA-related bone adaptations is crucial for addressing osteoporosis and osteoarthrosis.
Further research into subchondral bone changes can inform therapeutic strategies for bone and joint degeneration.