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Related Experiment Video

Updated: Jun 6, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Adiposity signaling and meal size control.

Timothy H Moran¹, Ellen E Ladenheim

¹Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. tmoran@jhmi.edu

Physiology & Behavior

|November 30, 2010

Summary

Hormones like insulin and leptin signal energy stores to regulate food intake. These signals modulate satiety signals, with the hindbrain acting as a key integration site for these feeding behaviors.

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Area of Science:

Neuroscience
Endocrinology
Physiology

Background:

Energy stores signal nutrient availability to regulate food intake.
Insulin and leptin act as adiposity signals influencing feeding behavior.
These signals modulate the efficacy of satiety signals within meals.

Purpose of the Study:

To review the role of energy store signaling in food intake regulation.
To highlight the mechanisms by which insulin and leptin affect satiety.
To discuss the integration of signals in the dorsal hindbrain.

Main Methods:

Review of seminal and recent studies on energy balance and feeding.
Analysis of hormonal signaling pathways (insulin, leptin).
Examination of neural circuits involved in satiety signal integration.

Main Results:

Hormones from energy stores modulate the efficacy of satiety signals.
Leptin influences multiple gut feedback signals.
The dorsal hindbrain integrates these signals, involving hypothalamic pathways.

Conclusions:

Energy balance hormones are crucial for regulating food intake.
The dorsal hindbrain is a key site for integrating satiety signals.
Understanding these pathways advances knowledge of feeding behavior and metabolic disorders.