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Updated: Jun 6, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Gastroesophageal reflux, eosinophilic esophagitis, and foreign body
1Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue MLC 2010, Cincinnati, OH 45229, USA.
Insights
Gastrointestinal issues are rare causes of chest pain in children, though conditions like eosinophilic esophagitis and GERD can occur. Most are not life-threatening, but diagnosis often requires further evaluation.
Area of Science:
- Pediatric Gastroenterology
- Pediatric Cardiology
Background:
- Chest pain is a frequent pediatric complaint, but gastrointestinal origins are uncommon.
- Identifying the precise cause of pediatric chest pain is crucial for appropriate management.
Purpose of the Study:
- To review common gastrointestinal conditions presenting as chest pain in children.
- To highlight the diagnostic considerations for these rare causes of pediatric chest pain.
Main Methods:
- Literature review of pediatric gastrointestinal disorders associated with chest pain.
- Analysis of clinical presentation, diagnostic workup, and management strategies.
Main Results:
- Four primary gastrointestinal conditions identified: eosinophilic esophagitis, gastroesophageal reflux disease, esophageal dysmotility, and foreign body ingestion.
- Most of these conditions, excluding certain foreign body ingestions, are not life-threatening.
- Clinical history and associated symptoms can guide diagnosis, but further investigations are frequently necessary.
Conclusions:
- Gastrointestinal causes of chest pain in children, while uncommon, necessitate thorough evaluation.
- Accurate diagnosis of conditions like eosinophilic esophagitis and GERD is essential for effective treatment.
- Distinguishing between benign and potentially serious gastrointestinal etiologies is key in pediatric chest pain management.
Abstract:
Even though chest pain in children is a common complaint, an underlying gastrointestinal cause is rare. The four common gastrointestinal conditions that present with chest pain include eosinophilic esophagitis, gastroesophageal reflux disease, esophageal dysmotility, and foreign body ingestion. Other than ingestion of certain foreign bodies, most of these conditions are not life-threatening. Associated symptoms and history may be helpful in distinguishing these disorders, but further evaluation is often indicated to identify the precise cause.
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