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Updated: Jun 6, 2026

Preparation of Rhythmically-active In Vitro Neonatal Rodent Brainstem-spinal Cord and Thin Slice
Published on: March 23, 2019
Genetic factors determining the functional organization of neural circuits controlling rhythmic movements the murine
J Champagnat1, M Thoby-Brisson, G Fortin
1Neurobiologie et Développement, UPR 3294, C.N.R.S., IFR 144 Neuro-Sud Paris, France.
Abstract:
In mammals, fetal movements governed by central pattern generators are essential for the development of adaptive behaviors such as breathing, walking, and chewing, which are vital after birth. Combining targeted mutations and genetic fate mapping can help to define the molecular determinants that control the development of these central pattern generators. In this chapter, recent results are presented on the embryonic parafacial (e-pF) rhythm generator, one of the two oscillators involved in controlling the breathing behavior and chemosensitive responsiveness.
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