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Related Concept Videos

Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Dry Friction01:30

Dry Friction

Dry friction occurs between two solid surfaces in contact as they attempt to move relative to one another. In daily life, dry friction is encountered in various forms, such as when walking on the ground, sliding an object across a table, or rubbing hands together. Despite its ubiquity, the underlying mechanisms behind dry friction are not readily visible.
To illustrate this concept, imagine a wooden crate resting on a rough, non-uniform horizontal surface. When an external force is applied to...
Rolling With Slipping01:14

Rolling With Slipping

Rolling with slipping is a physical phenomenon that occurs when a rolling object experiences both rotational and linear motion but also experiences frictional forces that cause slipping. This phenomenon can occur in various situations, such as when a tire rolls on a wet road or a ball rolls on a rough surface.
An object's rolling motion is characterized by its rotation around its axis, while linear motion refers to the object's translational motion along a surface. Frictional forces can affect...
Shearing Stress01:18

Shearing Stress

Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
Wood Surfacing01:14

Wood Surfacing

Wood surfacing is a critical finishing process designed to smoothen the wood surface, enhance its dimensional accuracy, and make handling safer. This process compensates for potential shrinkage during the seasoning phase by marginally increasing the wood dimensions before surfacing. It also helps correct some distortions that may occur as the wood dries.
The equipment used in the surfacing process is a plane equipped with rotating blades. This tool efficiently smoothens the wood surface and can...

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The Erv41-Erv46 complex serves as a retrograde receptor to retrieve misfolded secretory proteins that have escaped from the ER.

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The C-terminus of the cargo receptor Erv14 affects COPII vesicle formation and cargo delivery.

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Related Experiment Video

Updated: May 7, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

ER sheets get roughed up.

Charles Barlowe1

  • 1Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. charles.barlowe@dartmouth.edu

Cell
|November 30, 2010
PubMed
Summary

Proteins that form the endoplasmic reticulum's (ER) sheet structures are enriched by association with ribosomes. Curvature-inducing proteins are found at the edges of ER membrane sheets.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The endoplasmic reticulum (ER) membrane forms complex tubular and sheet structures.
  • The molecular mechanisms governing ER membrane organization are not fully understood.

Discussion:

  • Shibata et al. (2010) investigated the roles of specific proteins in ER membrane shaping.
  • Sheet-inducing proteins, like Climp-63, are localized to the rough ER through interactions with membrane-bound ribosomes.
  • Curvature-inducing proteins are found at the edges of membrane sheets, suggesting a role in forming tubular structures.

Key Insights:

  • Differential localization of ER-shaping proteins provides insights into membrane organization.
  • Association with ribosomes is crucial for the enrichment of sheet-shaping proteins in the rough ER.

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Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes

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Related Experiment Videos

Last Updated: May 7, 2026

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials
10:18

Exfoliation and Analysis of Large-area, Air-Sensitive Two-Dimensional Materials

Published on: January 5, 2019

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes
08:32

Electrochemical Roughening of Thin-Film Platinum Macro and Microelectrodes

Published on: June 30, 2019

  • Protein localization at specific membrane domains dictates their function in shaping ER architecture.
  • Outlook:

    • Further research can elucidate the precise interactions and dynamics of these proteins.
    • Understanding ER membrane shaping is critical for comprehending various cellular processes.
    • This study lays the groundwork for exploring therapeutic targets related to ER structure and function.