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Updated: Jun 6, 2026

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

Glycomics hits the big time.

Gerald W Hart1, Ronald J Copeland

  • 1Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21205-2185, USA. gwhart@jhmi.edu

Cell
|November 30, 2010
PubMed
Summary
This summary is machine-generated.

Cells utilize carbohydrates for energy. Glycans, diverse carbohydrate structures on proteins and lipids, are crucial for cellular functions and impact human diseases, as revealed by glycomics research.

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Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

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Last Updated: Jun 6, 2026

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Glycoscience

Background:

  • Carbohydrates are fundamental cellular energy sources.
  • Glycans, complex carbohydrate structures attached to proteins and lipids, represent the most abundant and diverse class of biomolecules.
  • Glycans play critical roles in numerous biological processes.

Purpose of the Study:

  • To highlight the functional significance of glycans in biological systems.
  • To underscore the impact of glycan structures on human health and disease.
  • To summarize recent advancements in the field of glycomics.

Main Methods:

  • Glycomics: The large-scale study of glycans.
  • Proteomics and Lipidomics: Analyzing glycan conjugation.
  • Bioinformatics: Interpreting glycomic data.

Main Results:

  • Glycans exhibit remarkable structural diversity.
  • Glycans are involved in a wide array of cellular functions.
  • Aberrant glycosylation patterns are associated with various human diseases.

Conclusions:

  • Glycans are essential molecules with profound biological functions.
  • Understanding glycan roles is crucial for deciphering disease mechanisms.
  • Advances in glycomics provide new insights into cellular processes and disease.
  • Glycan-focused research holds potential for therapeutic interventions.