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Updated: Jun 6, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
Published on: September 20, 2024
Rufinamide for refractory epilepsy in a pediatric and young adult population
Jacob R Joseph1, Rebecca J Schultz, Angus A Wilfong
1Pediatric Neurology, Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin, CC1710, Houston, TX 77030, USA.
Abstract:
This chart review investigated the efficacy and safety of rufinamide in 45 children and young adults who experienced a broad spectrum of partial and generalized seizure/epilepsy types which have been refractory to therapy. Of these patients, 19 (46%) achieved a >50% decrease in seizure frequency on rufinamide, and 7 patients achieved a >75% decrease in seizure frequency. While 17 (37.8%) patients stopped their trial of rufinamide prior to the end of the review period, only 2 (4.4%) were due to adverse effects. Although additional research must be done, this data shows promise that rufinamide is a safe and efficacious adjunct for cases of refractory epilepsy.
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