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Updated: Jun 6, 2026

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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Thiophene and bioisostere derivatives as new MMP12 inhibitors
Matthew Badland1, Delphine Compère, Karine Courté
1Evotec OAI, 151 Milton Park, Abingdon, Oxon OX14 SD, UK. matthew.badland@pfizer.com
Bioorganic & Medicinal Chemistry Letters
|November 30, 2010
Abstract:
A new MMP12 inhibitor series has been identified containing a thiophene moiety. Different approaches have been considered to replace this potential toxicophore. α-Fluorothiophene derivatives were the most interesting compounds. Their synthesis is presented.

