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Thiophene and bioisostere derivatives as new MMP12 inhibitors

Matthew Badland1, Delphine Compère, Karine Courté

  • 1Evotec OAI, 151 Milton Park, Abingdon, Oxon OX14 SD, UK. matthew.badland@pfizer.com

Bioorganic & Medicinal Chemistry Letters
|November 30, 2010
PubMed

Abstract:

A new MMP12 inhibitor series has been identified containing a thiophene moiety. Different approaches have been considered to replace this potential toxicophore. α-Fluorothiophene derivatives were the most interesting compounds. Their synthesis is presented.

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