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Updated: Jun 6, 2026
06:39
Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
Published on: February 18, 2020
Local drug delivery for percutaneous coronary intervention.
S Sharma1, C Christopoulos, N Kukreja
1East & North Herts NHS Trust, UK.
Pharmacology & Therapeutics
|November 30, 2010
Summary
Percutaneous coronary intervention (PCI) has advanced, but drug-eluting stents have risks. New local drug delivery technologies aim to improve PCI outcomes by reducing restenosis and thrombosis.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomedical Engineering
Background:
- Percutaneous coronary intervention (PCI) has evolved significantly since 1977.
- Drug-eluting stents (DES) were the standard but have limitations like in-stent restenosis and late stent thrombosis.
Purpose of the Study:
- To review the need for local drug therapy in PCI.
- To present novel technological advances in local pharmacotherapy delivery for coronary arteries.
Main Methods:
- Review of historical advancements in PCI.
- Discussion of limitations of current DES technology.
- Exploration of emerging local drug delivery systems.
Main Results:
- DES performance is limited by risks of in-stent restenosis and late stent thrombosis.
- New technologies offer potential solutions for local drug delivery in coronary arteries.
Conclusions:
- Local drug therapy is crucial for improving PCI outcomes.
- Emerging technologies may overcome DES limitations and represent future directions in coronary intervention.
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