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Hospital initiation of a vaccinal schedule improves the long-term vaccinal coverage of ex-preterm children

S Denizot1, J Fleury, G Caillaux

  • 1Department of Neonatal Medicine, Nantes University Hospital, Nantes, France. sophie.denizot@chu-nantes.Fr

Vaccine
|November 30, 2010
PubMed

Insights

Preterm infants often miss routine vaccinations. A study found that giving a primary vaccine before hospital discharge significantly improves vaccination rates for these vulnerable infants.

Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • Preterm infants face delays in routine immunizations.
  • Ensuring timely vaccination is crucial for protecting vulnerable infants from preventable diseases.

Purpose of the Study:

  • To evaluate the immunization status of preterm infants at 5 and 24 months.
  • To identify factors associated with achieving up-to-date vaccination coverage.

Main Methods:

  • Assessed vaccination status for DTaP, IPV, Hib, and pneumococcal conjugate vaccines in 602 preterm infants.
  • Analyzed data at 5 and 24 months corrected age.
  • Used logistic regression to adjust for gestational age and identify predictors of coverage.

Main Results:

  • At 5 months, only 39% were up-to-date for DTaP-IPV-Hib and 22% for pneumococcal conjugate vaccine.
  • By 24 months, coverage increased to 67% for DTaP-IPV-Hib and 36% for pneumococcal conjugate vaccine.
  • Receiving a primary vaccine before hospital discharge was strongly associated with better vaccination coverage (OR=5.0, p<.005).

Conclusions:

  • Preterm infants exhibit significant delays in achieving routine vaccination schedules.
  • Early vaccination, specifically a primary dose before discharge, is a key factor in improving immunization rates for preterm infants.
  • Interventions targeting pre-discharge vaccination may enhance long-term vaccine uptake in this population.

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