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Updated: Jun 6, 2026

High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
Published on: January 19, 2022
Mechanisms of mammalian ciliary motility: Insights from primary ciliary dyskinesia genetics
1Sanford Children's Health Research Center, Sanford Research USD, 2301 East 60th Street, Sioux Falls, SD 57104, USA. lance.lee@sanfordhealth.org
Abstract:
Motile cilia and flagella are organelles that, historically, have been poorly understood and inadequately investigated. However, cilia play critical roles in fluid clearance in the respiratory system and the brain, and flagella are required for sperm motility. Genetic studies involving human patients and mouse models of primary ciliary dyskinesia over the last decade have uncovered a number of important ciliary proteins and have begun to elucidate the mechanisms underlying ciliary motility. When combined with genetic, biochemical, and cell biological studies in Chlamydomonas reinhardtii, these mammalian genetic analyses begin to reveal the mechanisms by which ciliary motility is regulated.
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