Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypoglycemia

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...

Hypoglycemia and Glucagon

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...

Hormones Regulating Blood Glucose

Hormones Regulating Blood Glucose

Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...

Glucose Homeostasis: Regulation of Blood Glucose

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...

Hyperglycemia

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...

Metabolic States of the Body: The Postabsorptive State

Metabolic States of the Body: The Postabsorptive State

The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Swiss obesity clinical practice guidance.

Swiss medical weekly·2026

Same author

Assessing Irritability in Primary School-Aged Children: How to Test and Whom to Ask.

Children (Basel, Switzerland)·2025

Same author

A randomized controlled trial of an interactive digital therapeutic for stress and burnout management.

Npj mental health research·2025

Same author

Efficacy of a cognitive-behavioral digital therapeutic on psychosocial outcomes in cancer patients: A randomized controlled trial.

Journal of health psychology·2025

Same author

Mechanisms of change in the treatment of major depressive disorder with metacognitive therapy and behavioral activation - a random intercept cross-lagged panel and mediation analyses.

Psychotherapy research : journal of the Society for Psychotherapy Research·2025

Same author

Internet-based digital intervention to support the self-management of hypertension compared to usual care: results of the HALCYON randomized controlled trial.

BMC cardiovascular disorders·2025

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice

Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice

Published on: January 26, 2024

Sleep and the response to hypoglycaemia.

Kamila Jauch-Chara¹, Bernd Schultes

¹Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23638 Luebeck, Germany.

Best Practice & Research. Clinical Endocrinology & Metabolism

|November 30, 2010

Summary

Nocturnal hypoglycemia, or low blood sugar during sleep, is a frequent and dangerous complication for people with diabetes. It impairs awareness and can lead to serious health issues, including sudden death.

More Related Videos

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Establishing a Device for Sleep Deprivation in Mice

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Related Experiment Videos

Last Updated: Jun 6, 2026

Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice

Hyperglycemic Clamp and Hypoglycemic Clamp in Conscious Mice

Published on: January 26, 2024

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Establishing a Device for Sleep Deprivation in Mice

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

Area of Science:

Endocrinology
Metabolic Disorders
Sleep Medicine

Background:

Nocturnal hypoglycemia is a common yet often overlooked complication in diabetes management.
Sleep impairs the body's natural defense mechanisms against falling blood glucose levels.
This can lead to reduced awareness and potentially severe health consequences, including cardiac events.

Purpose of the Study:

To review the current understanding of nocturnal hypoglycemia in diabetic patients.
To highlight the challenges in detecting and preventing hypoglycemia during sleep.
To discuss the implications for patient well-being and mortality.

Main Methods:

Literature review of studies on nocturnal hypoglycemia in type 1 and type 2 diabetes.
Analysis of physiological responses to hypoglycemia during sleep.
Examination of existing and potential strategies for prevention and detection.

Main Results:

Patients with diabetes, particularly type 1, often fail to awaken during nocturnal hypoglycemia.
Sleep lowers the threshold for counterregulatory hormone release, increasing vulnerability.
The frequency and response to nocturnal hypoglycemia in type 2 diabetes require further investigation.

Conclusions:

Nocturnal hypoglycemia is a significant problem in diabetes care, impacting patient safety and quality of life.
Current strategies for prevention and detection are insufficient.
Further research and clinical attention are needed to address this critical issue.