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Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
Published on: July 31, 2021
Teratogenicity and maternal effects of Lactobacillus brevis KB290 in rats and rabbits
T Yakabe1, H Takashima, M Kuwagata
1Research Institute, Kagome Co, Ltd, Tochigi, Japan. Takafumi_Yakabe@kagome.co.jp
Abstract:
Lactobacillus brevis KB290 (KB290), a plant-derived probiotic lactic acid bacterium, improves gut health and stimulates immune function. Here we extensively investigated the teratogenicity of KB290 in rats and rabbits. We observed no adverse maternal or fetal effects and concluded that the no observable adverse effect level for maternal general toxicity, maintenance of pregnancy, and teratogenicity should be ≥ 10(10) cfu/kg/day. Our results suggest that KB290 would be safe for pregnant females and their offspring.
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