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Supported treadmill ambulation for amyotrophic lateral sclerosis: a pilot study.

Mohammed Sanjak1, Elena Bravver, William L Bockenek

  • 1Carolinas Neuromuscular/ALS-MDA Center, Department of Neurology, Neuroscience and Spine Institute, Charlotte, NC, USA. mohammed.sanjak@carolinashealthcare.org

Archives of Physical Medicine and Rehabilitation
|November 30, 2010
PubMed
Summary

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Supported treadmill ambulation training (STAT) is a feasible, safe, and well-tolerated exercise for amyotrophic lateral sclerosis (ALS) patients. This repetitive rhythmic exercise improved gait function and work capacity in individuals with ALS who use assistive devices.

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Exercise Physiology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting motor neurons.
  • Patients with ALS often experience progressive gait impairment and reduced exercise capacity.
  • Supported Treadmill Ambulation Training (STAT) is an emerging intervention for improving functional mobility.

Purpose of the Study:

  • To assess the feasibility, tolerability, safety, and exercise treatment effect of STAT in ambulatory patients with ALS.
  • To evaluate the impact of STAT on functional measures, gait performance, and muscle strength.
  • To determine the potential of STAT as a therapeutic intervention for individuals with ALS.

Main Methods:

  • An interventional, repeated-measures study design was employed.

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  • Nine ambulatory patients with ALS (Sinaki-Mulder stages II-III) using assistive devices participated.
  • Participants underwent 8 weeks of STAT, 3 times weekly, with specific exercise and rest intervals.

    • Main Results:

    • The STAT intervention was found to be feasible, tolerated, and safe, with no decrease in key safety measures (ALSFRS-R, VC, MMT).
    • Significant improvements were observed in gait speed, distance, and stride length during treadmill and ground 6-minute walk tests after 4 weeks, maintained at 8 weeks.
    • While some measures like walking speed and lower-extremity MVIC showed improvement, they did not reach statistical significance.

    Conclusions:

    • Repetitive rhythmic exercise via STAT is feasible, tolerated, and safe for patients with ALS.
    • STAT demonstrates a consistent treatment effect size, improving work capacity and gait function in ALS patients reliant on assistive devices.
    • Further investigation in larger studies is warranted to confirm the stability of these functional improvements in relation to ALS progression.