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Related Experiment Video

Updated: Jun 6, 2026

Operant Sensation Seeking in the Mouse
08:39

Operant Sensation Seeking in the Mouse

Published on: November 10, 2010

Operant sensation seeking in the mouse.

Christopher M Olsen1, Danny G Winder

  • 1Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Kennedy Center for Human Development, Vanderbilt University Medical Center, USA. chris.olsen@vanderbilt.edu

Journal of Visualized Experiments : Jove
|November 30, 2010
PubMed
Summary

Operant sensation seeking (OSS) offers a catheter-free method to study sensory reinforcement mechanisms. Dopamine D1 receptor knockout mice fail to acquire OSS, suggesting shared neural pathways with drug addiction.

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Addiction Research

Background:

  • Operant self-administration methods are crucial for studying motivated behavior and addiction.
  • Intravenous drug self-administration in mice faces technical challenges like catheter patency, leading to high attrition rates.
  • Existing methods using food reinforcement may not fully capture the complexities of drug addiction mechanisms.

Purpose of the Study:

  • To introduce and validate the operant sensation seeking (OSS) model for studying sensory reinforcement in mice.
  • To investigate the role of dopamine D1 receptors in sensory reinforcement and its relevance to addiction.
  • To compare OSS with food self-administration models for studying motivated behavior and addiction.

Main Methods:

  • Utilized the operant sensation seeking (OSS) model for sensory self-administration in mice.

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Related Experiment Videos

Last Updated: Jun 6, 2026

Operant Sensation Seeking in the Mouse
08:39

Operant Sensation Seeking in the Mouse

Published on: November 10, 2010

Quantifying Social Motivation in Mice Using Operant Conditioning
07:43

Quantifying Social Motivation in Mice Using Operant Conditioning

Published on: August 8, 2015

An Operant Intra-/Extra-dimensional Set-shift Task for Mice
08:35

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

  • Employed dopamine D1 receptor knockout mice to assess the genetic basis of sensory reinforcement.
  • Compared operant behavior in response to sensory, food, and drug reinforcers.

    • Main Results:

    • Dopamine D1 receptor knockout mice failed to acquire operant sensation seeking (OSS), despite being able to learn operant tasks with food reinforcement.
    • This suggests that dopamine D1 receptors play a role in sensory reinforcement, potentially overlapping with mechanisms of drug addiction.
    • OSS avoids the technical difficulties of intravenous drug self-administration, allowing for higher throughput genetic and pharmacological studies.

    Conclusions:

    • Operant sensation seeking (OSS) is a viable and advantageous model for studying sensory reinforcement and its neural mechanisms.
    • OSS may serve as a valuable preclinical model for investigating aspects of drug addiction, particularly those involving dopamine D1 receptor signaling.
    • The model offers a catheter-free alternative to traditional drug self-administration, facilitating broader research into motivated behaviors and addiction.