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Skin Microvascular Thrombosis in Fusarium Infection in Two Early Biopsied Cases

Yang Fan1, Lise Willems, Christophe Leboeuf

  • 1Inserm, U728, Service de Pathologie, Paris, France.

Case Reports in Dermatology
|November 30, 2010
PubMed

Insights

Early skin biopsies showing Fusarium fungal hyphae in microvessels can rapidly diagnose disseminated infections in immunocompromised patients, enabling prompt antifungal treatment.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatopathology

Background:

  • Fusarium species are increasingly causing severe infections, particularly in immunocompromised individuals.
  • Rapid dissemination and antifungal resistance necessitate early diagnostic methods for Fusarium infections.

Observation:

  • Two cases of Fusarium infection presented with initial cutaneous lesions.
  • Early skin biopsies revealed microvessel thrombosis containing fungal hyphae.

Findings:

  • Histopathological identification of hyphae within cutaneous microvessel thrombi strongly suggested disseminated Fusarium infection.
  • Skin cultures confirmed Fusarium species as the causative agent.

Implications:

  • Early diagnosis of Fusarium infection via cutaneous biopsies can be life-saving.
  • Identifying microvessel thrombosis in skin biopsies can prompt timely antifungal therapy, even in healthy hosts.

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