Related Experiment Video
Updated: Jun 6, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
Published on: May 31, 2024
Pneumatosis Coli Associated with Pseudomembranous Colitis in a Patient following Colonic Surgery
Jennifer Bailey1, Eldon A Shaffer
1Division of Gastroenterology, Faculty of Medicine, University of Calgary, Teaching Research & Wellness Building, Room 6D48, 3280 Hospital Dr NW, Calgary, AB, Canada T2N4N1.
Abstract:
Pneumatosis intestinalis is a rare disorder characterized by gas-filled cysts within the subserosal and/or submucosal regions of the intestinal wall. The source of this gas and its translocation across the mucosa is incompletely understood. Most (85%) cases are associated with medical conditions, ranging from psychiatric through respiratory disorders to gastrointestinal-related diseases; the remaining 15% lack any recognizable cause or association. In this case report, pneumatosis coli (affecting the colon) occurred in a patient following abdominal surgery and was associated with pseudomembranous colitis, which was Clostridium difficile toxin negative-presumably a false negative. Supportive care and appropriate antibacterial agents sufficed to alleviate symptoms and resolve the pneumatosis. Recognizing this uncommon but important association can avoid high financial and personal costs from unnecessary testing and invasive surgical explorations. Consideration should be given to pseudomembranous colitis as the basis for pneumatosis coli developing in patients who have received antibiotics, once gut ischemia has been ruled out.
Insights
Pneumatosis intestinalis, a rare condition of gas in the intestinal wall, can be linked to pseudomembranous colitis, especially after antibiotic use. Early recognition aids treatment and avoids unnecessary procedures.
Area of Science:
- Gastroenterology
- Internal Medicine
Background:
- Pneumatosis intestinalis is a rare condition characterized by gas cysts in the intestinal wall, with unclear etiology in 15% of cases.
- Most cases are secondary to underlying medical conditions, including gastrointestinal diseases.
Observation:
- A case of pneumatosis coli occurred post-abdominal surgery in a patient with pseudomembranous colitis.
- The pseudomembranous colitis tested negative for Clostridium difficile toxin, suggesting a potential false negative.
Findings:
- Supportive care and antibiotics effectively resolved the pneumatosis coli and associated symptoms.
- This case highlights an uncommon association between pneumatosis coli and pseudomembranous colitis.
Implications:
- Recognizing this association can prevent costly and invasive diagnostic procedures.
- Pseudomembranous colitis should be considered in antibiotic-exposed patients with pneumatosis coli, after ruling out gut ischemia.
Related Concept Videos
Diverticular Disease of the Colon
Intestinal Obstruction II: Pathophysiology
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease II: Ulcerative Colitis
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
