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Updated: Jun 6, 2026
07:25
Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
Published on: January 5, 2021
Myc, mondo, and metabolism
Elizabeth J Sloan1, Donald E Ayer
1Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA.
Genes & Cancer
|November 30, 2010
Summary
The Myc and Mondo transcriptional regulators control cell growth by regulating metabolic pathways. Their cooperation is crucial for cancer cell metabolism, offering new therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Metabolism
Background:
- The Myc family of proto-oncogenes is central to tumorigenesis.
- Identifying specific Myc transcriptional targets for its oncogenic function is challenging.
- Myc regulates multiple metabolic pathways linked to cell growth, division, and death.
Purpose of the Study:
- To explore metabolic pathways regulated by Myc and Mondo.
- To investigate the cooperation between Myc and Mondo in controlling cancer cell metabolism.
- To understand Myc's pleiotropic role in cell growth and division through its regulated pathways.
Main Methods:
- Review of existing literature on Myc and Mondo transcriptional regulators.
- Analysis of Myc's direct regulation of metabolic pathways, including glycolysis and biosynthesis.
- Examination of the Mondo family's role as a sensor of intracellular bioenergetic charge and glucose metabolism.
Main Results:
- Myc directly regulates numerous biosynthetic pathways essential for cell growth and division.
- The Mondo family interacts with Myc and senses intracellular energy levels.
- Myc and Mondo play roles in controlling glucose availability and utilization.
Conclusions:
- Focusing on Myc-regulated pathways provides insight into its role in cell growth and death.
- The cooperation between Myc and Mondo in cancer cell metabolism is a significant area for future research.
- Understanding these metabolic regulations may lead to novel cancer therapies.
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