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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

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Related Experiment Video

Updated: Jun 6, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Osteoporosis in men: what has changed?

Robert A Adler1

  • 1Endocrinology and Metabolism, McGuire Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA. robert.adler@va.gov

Current Osteoporosis Reports
|November 30, 2010
PubMed
Summary

Osteoporosis in men is increasingly recognized, especially after hip fractures. Screening methods and FDA-approved therapies are improving bone density and reducing fractures in men, including those on androgen deprivation therapy.

Area of Science:

  • Endocrinology
  • Geriatrics
  • Orthopedics

Background:

  • Osteoporosis in men is a growing concern due to higher mortality rates post-hip fracture.
  • Current screening methods include dual energy x-ray absorptiometry and fracture risk calculators like FRAX.
  • Evaluation often reveals secondary causes and multiple risk factors for osteoporosis in men.

Purpose of the Study:

  • To review the current understanding and management of osteoporosis in men.
  • To highlight advancements in screening, diagnosis, and therapeutic options.
  • To emphasize the importance of addressing bone health in men, particularly those undergoing androgen deprivation therapy.

Main Methods:

  • Review of existing literature on male osteoporosis screening and treatment.

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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

  • Analysis of FDA-approved therapies for osteoporosis in men.
  • Examination of studies evaluating bone density and fracture reduction in men on androgen deprivation therapy.

    • Main Results:

    • Dual energy x-ray absorptiometry and fracture risk calculators are key screening tools.
    • Several pharmacologic agents, including bisphosphonates and teriparatide, are FDA-approved for male osteoporosis.
    • Denosumab shows promise in increasing bone density and reducing vertebral fractures in men on androgen deprivation therapy.

    Conclusions:

    • Significant progress has been made in recognizing and managing osteoporosis in men.
    • Therapeutic options are expanding, offering improved bone health outcomes.
    • Continued research and clinical attention are crucial for addressing male osteoporosis effectively.