Related Experiment Video
Updated: Jun 6, 2026
05:39
A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
Published on: June 13, 2025
The relation between ADHD symptoms and fine motor control: a genetic study
Tinca J C Polderman1, Jenny van Dongen, Dorret I Boomsma
1Department of Biological Psychology, VU University Amsterdam, The Netherlands. tinca.polderman@cncr.vu.nl
Summary
Fine motor control (MC) in children with ADHD symptoms showed weak associations with performance, suggesting it is not a reliable endophenotype. Genetic and environmental factors influenced MC, but not strongly linked to ADHD.
Area of Science:
- Neurodevelopmental disorders
- Behavioral genetics
Background:
- Previous studies suggest shared genetic factors between ADHD and fine motor control (MC).
- Motor control (MC) has been proposed as a potential endophenotype for ADHD.
Purpose of the Study:
- To investigate the association between ADHD symptoms (AS) and MC.
- To differentiate between genetic and non-genetic familial influences on this association.
Main Methods:
- Utilized a genetically informative twin and sibling study design (N=409, age 12).
- Assessed ADHD symptoms (AS) using the SWAN scale.
- Measured MC accuracy and stability via the ANT computerized pursuit task.
- Employed Structural Equation Modelling for analysis.
Main Results:
- Weak phenotypic associations found between AS and MC accuracy (r = -.10/-.10).
- No significant association between AS and MC stability (r = -.01/-.03).
- AS were highly heritable (75%); MC accuracy and stability showed limited genetic influence.
- A low genetic correlation (r = -.14) was observed between AS and left-hand MC accuracy.
Conclusions:
- The phenotypic and genetic links between ADHD symptoms and computerized fine motor control are weak.
- Fine motor control is unlikely to be a suitable endophenotype for ADHD.
Related Concept Videos
01:30Attention-Deficit/Hyperactivity Disorder
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
01:28Human Genetics
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
01:23Behavioral Genetics and Its Designs
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
01:20Gene-Environment Interactions
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
01:19Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
01:11Genetic Lingo
Overview