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[Protected effects of MG-132 on apoptosis induced by deltamethrin in rat's hippocampus]
Xiao-Wei Huang1, Yan Qing, Yan-fang Liang
1Department of Health Toxicology,School of Public Health, Tonji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Objective:
To study the protective effect of MG-132 on hippocampus cells apoptosis induced by deltamethrin (DM), one kind of pyrethroid pesticide.
Methods:
40 Male wistar rats were randomly divided into four groups: olive oil control, DM treated alone (12.5 mg/kg), MG-132 (0.5 mg/kg) plus DM group, MG-132 treated 2h plus olive oil. After 24h treatment of DM, the hippocampus was taken out to detect the apoptotic cell rate, the level of bcl-2 and Caspase-3 activity.
Results:
Compared with DM treated alone group (27.29% +/- 2.41%), the apoptotic cell rate in MG-132 + DM group (19.94% +/- 2.07%) was increased (P < 0.05), bcl-2 expression was enhanced [(0.43 +/- 0.06) vs. (2.01 +/- 0.23)] (P < 0.05) and the activity of Caspase-3 was decreased significantly (P < 0.05) in MG-132 treated 2h plus DM group [(4.55 +/- 0.46) vs.(3.73 +/- 0.35)].
Conclusion:
MG-132 can protect hippocampus cells against apoptosis induced by deltamethrin.
