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The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
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Published on: April 28, 2015

Novel multi-functional life support system.

David P Webb1, Darren Jackson, Ehab S Kasasbeh

  • 1Vanderbilt Heart Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

The Journal of Extra-Corporeal Technology
|December 1, 2010
PubMed
Summary
This summary is machine-generated.

A novel multi-functional life support system (MLS) offers a portable, economical solution for various cardiopulmonary support needs. This system streamlines extracorporeal membrane oxygenation (ECMO) and ventricular support applications across diverse clinical settings.

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Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering

Background:

  • Established cardiopulmonary support (CPS), extracorporeal membrane oxygenation (ECMO), and ventricular support (VS) systems are often complex, costly, and require specialized expertise.
  • Existing perfusion adjuncts necessitate significant financial investment for acquisition, maintenance, deployment, and utilization.

Purpose of the Study:

  • To introduce and evaluate a novel, multi-functional life support (MLS) system designed for rapid deployment, user-friendliness, portability, safety, and cost-effectiveness.
  • To demonstrate the versatility and efficacy of the MLS across various clinical scenarios within a single year.

Main Methods:

  • The MLS was implemented and utilized over a 1-year period in diverse clinical environments, including cardiac catheterization labs, cardiovascular intensive care units, and cardiac surgical suites.
  • The system facilitated multiple intra-hospital transports and one inter-facility transport.
  • Applications encompassed a wide range of procedures and conditions requiring advanced hemodynamic support.

Main Results:

  • The MLS was successfully applied in numerous critical interventions, including ECMO, cardiopulmonary resuscitation-supported cardiogenic shock, high-risk percutaneous coronary intervention (PCI), and valvuloplasty.
  • It enabled seamless transitions for ventricular assist devices (VADs) to ECMO and facilitated ECMO to conventional cardiopulmonary bypass (CPB) procedures.
  • Support durations varied significantly, ranging from approximately 39 minutes to several days, highlighting system adaptability.

Conclusions:

  • The novel MLS provides a versatile, economical, and user-friendly platform for advanced cardiopulmonary and ventricular support.
  • Its successful application across multiple clinical settings and diverse patient conditions underscores its potential to enhance patient care and reduce the burden associated with traditional support systems.
  • The system's portability and ease of use facilitate its deployment in various scenarios, including inter-facility transport.