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Updated: Apr 1, 2026

Author Spotlight: Biological Standardization to Ensure Reproducibility and Harmonization in Research
Published on: August 4, 2023
Before you analyze a human specimen, think quality, variability, and bias
Mark David Lim1, Anthony Dickherber, Carolyn C Compton
1AAAS Science and Technology Policy Fellowship Program and National Cancer Institute, National Institutes of Health, USA.
Analytical chemists are crucial for personalized medicine, developing sensitive biomarker detection methods. Early involvement in experimental design is essential for complex biospecimen analysis in translational research.
Area of Science:
- Biomarker discovery and analytical chemistry
- Translational research methodologies
Background:
- Personalized medicine necessitates advanced biomarker detection.
- Analytical chemists play a key role in developing these sensitive methods.
- Biospecimen analysis presents significant experimental design challenges.
Purpose of the Study:
- Highlight the critical role of analytical chemists in personalized medicine.
- Emphasize the need for analytical scientists' early involvement in research design.
- Address the complexities of biospecimen analysis.
Main Methods:
- Review of current analytical techniques for biomarker measurement.
- Discussion of experimental design considerations for biospecimen analysis.
- Case studies illustrating the impact of analytical chemistry in translational research.
Main Results:
- Analytical methods are advancing in specificity and sensitivity.
- Early integration of analytical scientists improves research outcomes.
- Complexities in biospecimen handling and analysis are being addressed.
Conclusions:
- Analytical chemists are essential for advancing personalized medicine.
- Proactive engagement of analytical scientists in experimental design is vital.
- Continued innovation in analytical techniques will drive translational research.
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