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Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis in Denmark 1994-2006: a nationwide

R Tuckuviene1, A L Christensen, J Helgestad

  • 1Department of Clinical Biochemistry, Centre of Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. rt@rn.dk

Acta Paediatrica (Oslo, Norway : 1992)
|December 1, 2010
PubMed

Insights

The incidence of pediatric arterial ischemic stroke (AIS) is rising annually, particularly in infants. Cerebral sinovenous thrombosis (CSVT) also peaks in infancy and adolescence, but its incidence remains stable.

Area of Science:

  • Neurology
  • Pediatrics
  • Epidemiology

Background:

  • Pediatric arterial ischemic stroke (AIS) and cerebral sinovenous thrombosis (CSVT) are rare but serious neurological conditions in children.
  • Understanding their incidence, risk factors, and outcomes is crucial for improving diagnosis and management.

Purpose of the Study:

  • To determine the incidence rates (IR) of pediatric AIS and CSVT.
  • To characterize clinical features, risk factors, treatments, and outcomes for these conditions.

Main Methods:

  • A population-based study using nationwide medical registries in Denmark.
  • Inclusion of all patients aged 0-18 years hospitalized with first-ever AIS and/or CSVT between 1994 and 2006.
  • Review of retrieved medical records for detailed data extraction.

Main Results:

  • Identified 211 AIS and 40 CSVT cases, with IRs of 1.33 and 0.25 per 100,000 person-years, respectively.
  • Incidence peaked in infancy for both AIS and CSVT, with an additional adolescent peak for CSVT.
  • AIS incidence increased 3.9% annually; CSVT incidence remained stable. 48.2% received antithrombotic treatment with no major complications. 30-day fatality was 3.6%, and 56.2% experienced neurological sequelae.

Conclusions:

  • Pediatric AIS incidence is increasing, especially in infants.
  • CSVT incidence shows peaks in infancy and adolescence but has not changed significantly over time.
  • Neurological sequelae are common following these events, highlighting the need for effective interventions.
Abstract

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