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Association between AMELX polymorphisms and dental caries in Koreans
1Department of Oral Pathology and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea.
Oral Diseases
|December 1, 2010
Summary
Genetic variations in the AMELX gene, specifically single nucleotide polymorphisms (SNPs) rs5933871 and rs5934997, are linked to dental caries susceptibility. These findings suggest a genetic component influencing tooth decay risk in the Korean population.
Area of Science:
- Genetics
- Dentistry
- Human Biology
Background:
- Dental caries is a multifactorial disease influenced by environmental factors.
- Emerging evidence highlights a genetic predisposition to caries susceptibility.
- The AMELX gene, encoding amelogenin, is crucial for normal enamel formation.
Purpose of the Study:
- To investigate the association between dental caries and single nucleotide polymorphisms (SNPs) in the AMELX gene.
- To explore the role of genetic factors in caries susceptibility.
- To analyze specific AMELX gene SNPs in relation to dental caries experience.
Main Methods:
- DNA samples from 120 individuals over 12 years old were analyzed.
- Dental status was assessed using WHO criteria, evaluating DMFT and DMFS indices.
- Genotyping of three AMELX SNPs (rs17878486, rs5933871, rs5934997) was performed using direct sequencing and SNPStats analysis.
Main Results:
- Significant associations were found between the rs5933871 and rs5934997 SNPs and caries susceptibility.
- These associations were particularly noted within the water fluoridation group.
- No significant association was reported for the rs17878486 SNP.
Conclusions:
- Single nucleotide polymorphisms (SNPs) in the AMELX gene may be associated with dental caries susceptibility.
- The findings suggest a potential genetic influence on caries risk in the Korean population.
- Further research is warranted to elucidate the precise mechanisms linking AMELX gene variations to dental caries.
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