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Dose response biology: the case of resveratrol

Edward J Calabrese1, Mark P Mattson, Vittorio Calabrese

  • 1Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003,USA. edwardc@schoolph.umass.edu

Human & Experimental Toxicology
|December 1, 2010
PubMed

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Pharmacodynamics explores the relationship between drug concentration and its effect. In a quantal response drug, the duration of action better correlates with drug concentration, while for graded effect drugs, the intensity of response is more relevant. This intensity depends on the dose, drug removal rate, and the region of the concentration–response curve.The concentration–response curve can be divided into three regions. Region 3 (80–100% maximum response) demonstrates that even as drug...