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Related Concept Videos

S-Cdk Initiates DNA Replication02:38

S-Cdk Initiates DNA Replication

The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of replication.
S-Cdk Initiates DNA Replication02:38

S-Cdk Initiates DNA Replication

The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of replication.
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...

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Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity.

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Transcription elongation can be sufficient, but is not necessary, to advance replication timing.

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Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks.

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Microhomology-mediated end joining acts directly on replication forks to repair single-ended double strand breaks.

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An integrated view of the structure and function of the human 4D nucleome.

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Related Experiment Video

Updated: Jun 6, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
08:06

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement

Published on: January 19, 2017

Cell fate transitions and the replication timing decision point.

David M Gilbert1

  • 1Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. gilbert@bio.fsu.edu

The Journal of Cell Biology
|December 1, 2010
PubMed
Summary

The replication timing decision point (TDP) is a brief G1 phase window where 3D chromatin architecture remodels. Extracellular cues may influence stem cell fate decisions by impacting this critical TDP window.

Area of Science:

  • Genomics
  • Cell Biology
  • Developmental Biology

Background:

  • Recent findings indicate significant three-dimensional (3D) chromatin architecture remodeling.
  • This remodeling occurs during a specific, brief window in early G1 phase.
  • This period is known as the replication timing decision point (TDP).

Purpose of the Study:

  • To propose that the replication timing decision point (TDP) is a critical window.
  • To suggest that extracellular cues can influence 3D chromatin architecture.
  • To explore the role of TDP in stem cell fate decisions.

Main Methods:

  • This is a speculative article.
  • It proposes a hypothesis based on current findings.
  • It outlines testable predictions for future research.

More Related Videos

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
17:14

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

Published on: December 10, 2012

Related Experiment Videos

Last Updated: Jun 6, 2026

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement
08:06

Genome-wide Determination of Mammalian Replication Timing by DNA Content Measurement

Published on: January 19, 2017

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome
06:40

G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
17:14

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

Published on: December 10, 2012

Main Results:

  • The replication timing decision point (TDP) may be an underappreciated point of influence.
  • Extracellular signals could potentially guide stem cell fate through TDP.
  • Several experimental predictions are presented to test this hypothesis.

Conclusions:

  • The replication timing decision point (TDP) presents a novel target for understanding stem cell differentiation.
  • Investigating extracellular cue interactions with TDP could reveal new mechanisms in developmental biology.
  • Further research is needed to validate the proposed role of TDP in stem cell fate determination.