Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Introduction to Scalers

Introduction to Scalers

Many familiar physical quantities can be specified completely by giving a single number and the appropriate unit. For example, "a class period lasts 50 min," or "the gas tank in my car holds 65 L," or "the distance between the two posts is 100 m." A physical quantity that can be specified completely in this manner is called a scalar quantity. The word "scalar" is a synonym for "number." Time, mass, distance, length, volume, temperature, and energy are some examples of scalar quantities.
Scalar...

Scale-Up Processes

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

De-risking rare disease acquisitions: a win-win-win for patients, biotech and investors.

Nature reviews. Drug discovery·2023

Same author

The Fidget Factor and the obesity paradox. How small movements have big impact.

Frontiers in sports and active living·2023

Same author

Effects of Experimental Sleep Restriction on Energy Intake, Energy Expenditure, and Visceral Obesity.

Journal of the American College of Cardiology·2022

Same author

Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers.

Frontiers in human neuroscience·2020

Same author

Acceptability of Robotic-Assisted Exercise Coaching Among Diverse Youth: Pilot Study.

JMIR pediatrics and parenting·2019

Same author

Accuracy of Accelerometers for Measuring Physical Activity and Levels of Sedentary Behavior in Children: A Systematic Review.

Journal of primary care & community health·2019

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Scalable Obesity Solutions (S.O.S.).

James A Levine¹

¹Mayo Clinic, Rochester, MN, USA.

Journal of Physical Activity & Health

|December 1, 2010

Summary

This summary is machine-generated.

The obesity epidemic requires immediate intervention. This paper outlines a framework for designing, building, and deploying Scalable Obesity Solutions (S.O.S.) to effectively contain and reverse the growing global health crisis.

More Related Videos

Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice

Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice

Published on: February 10, 2023

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Related Experiment Videos

Last Updated: Jun 6, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice

Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice

Published on: February 10, 2023

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Area of Science:

Public Health
Epidemiology
Health Policy

Background:

Obesity is a primary driver of chronic diseases and escalating healthcare costs globally.
The obesity epidemic disproportionately affects developed nations and is increasingly prevalent in low and middle-income countries.
Current healthcare systems struggle to manage the financial burden of obesity-related illnesses.

Purpose of the Study:

To present a comprehensive strategy for reversing the global obesity epidemic.
To detail the design, development, and dissemination of mass-scalable obesity containment interventions.
To introduce the Scalable Obesity Solutions (S.O.S.) framework.

Main Methods:

Conceptualization of a multi-faceted approach to obesity containment.
Development of scalable strategies for widespread implementation.
Planning for the deployment and dissemination of obesity control measures.

Main Results:

A viable know-how exists to reverse the obesity epidemic.
The proposed Scalable Obesity Solutions (S.O.S.) framework offers a direct response to mitigate obesity's health and economic impacts.
The paper provides a roadmap from concept to deployment for obesity containment.

Conclusions:

Reversing the obesity epidemic is a societal imperative.
Implementing Scalable Obesity Solutions (S.O.S.) is crucial for public health and economic sustainability.
A proactive, scalable approach is more effective than solely managing obesity's consequences.