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Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Related Experiment Video

Updated: Jun 6, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Infection and chronic allograft dysfunction.

Peter J Dupont1, Oriol Manuel, Manuel Pascual

  • 1Department of Nephrology and Transplantation, Royal Free Hospital, London, UK. peter.dupont@royalfree.nhs.uk

Kidney International. Supplement
|December 1, 2010
PubMed
Summary
This summary is machine-generated.

Despite reduced acute rejection in kidney transplants, long-term graft survival is hampered by infections. Polyoma virus, cytomegalovirus, and bacterial infections are key threats to allograft health.

Related Experiment Videos

Last Updated: Jun 6, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Infectious Diseases

Background:

  • Potent immunosuppression has decreased acute renal transplant rejection rates.
  • Suboptimal long-term graft survival persists due to cumulative insults.
  • Infectious complications are increasingly recognized as major causes of allograft dysfunction.

Purpose of the Study:

  • To highlight the emerging role of infectious diseases in chronic allograft dysfunction.
  • To identify specific pathogens contributing to long-term graft loss.
  • To underscore the need for vigilance against infections post-transplantation.

Main Methods:

  • Review of recent literature on renal transplant outcomes.
  • Analysis of causes of graft injury beyond acute rejection.
  • Categorization of infectious agents implicated in allograft dysfunction.

Main Results:

  • Infections such as polyoma virus nephropathy, cytomegalovirus disease, and bacterial infections are significant causes of allograft dysfunction.
  • Hepatitis C-associated cryoglobulinemia, Epstein-Barr virus-associated lymphoproliferative disease, adenoviral, and parvovirus B19 infections are rarer causes.
  • These infectious agents contribute to chronic allograft dysfunction and loss.

Conclusions:

  • While acute rejection is less common, infectious diseases pose a persistent threat to long-term renal allograft survival.
  • Effective management and prevention of infections are crucial for improving outcomes in kidney transplant recipients.
  • Further research into pathogen-specific therapies and surveillance is warranted.