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Related Experiment Video

Updated: Jun 6, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Ocular Tuberculosis Initially Presenting as Central Retinal Vein Occlusion.

Muiz Mahyudin¹, May May Choo, Norlina Mohd Ramli

¹University Malaya Medical Centre, Kuala Lumpur, Malaysia.

Case Reports in Ophthalmology

|December 1, 2010

Summary

Ocular tuberculosis, a rare condition, can mimic central retinal vein occlusion. Early diagnosis using polymerase chain reaction (PCR) is crucial for effective antituberculosis therapy and vision improvement.

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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

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Published on: August 6, 2021

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Last Updated: Jun 6, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

Area of Science:

Ophthalmology
Infectious Diseases
Microbiology

Background:

Central retinal vein occlusion (CRVO) is a common cause of vision loss.
Retinal vasculitis can be associated with various systemic and infectious causes.
Ocular tuberculosis is rare and often presents without systemic signs.

Observation:

A young man presented with CRVO that progressed to retinal vasculitis and severe vision loss.
Initial investigations, including Mantoux test and chest X-ray, were negative for tuberculosis.
Fundus fluorescein angiography confirmed retinal vasculitis, unresponsive to corticosteroid therapy.

Findings:

Polymerase chain reaction (PCR) analysis of vitreous fluid detected Mycobacterium tuberculosis.
This confirmed ocular tuberculosis as the underlying cause of the patient's symptoms.
A 6-month course of antituberculosis therapy led to inflammation subsidence and vision improvement.

Implications:

This case highlights the importance of considering tuberculosis in unexplained retinal vasculitis, even without systemic evidence.
PCR analysis of ocular fluids is a valuable diagnostic tool for ocular tuberculosis.
Prompt diagnosis and treatment of ocular tuberculosis can significantly improve visual outcomes.