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Updated: Aug 31, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

[Changes in mitral and tricuspid blood flow as a function of aging. Value of a combined study with Doppler

S Legeais1, S Gaucher, C Veyrat

  • 1Service de cardiologie, fondation A. de Rothschild, Paris.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|April 1, 1990
PubMed

Insights

As people age, changes in heart valve blood flow occur. Specifically, the E wave amplitude and velocity time integral decrease, while the A wave increases, impacting diastolic function assessment.

Area of Science:

  • Cardiology
  • Physiology
  • Medical Imaging

Context:

  • Mitral and tricuspid diastolic flow are influenced by numerous physiological factors.
  • Interpreting these flow patterns can be challenging, especially with age-related changes.
  • Doppler echocardiography is a key tool for assessing cardiac blood flow dynamics.

Purpose:

  • To investigate age-related alterations in blood flow through the mitral and tricuspid atrioventricular orifices.
  • To establish tricuspid flow as a reference for evaluating changes in mitral flow.
  • To analyze the impact of age on specific Doppler echocardiographic parameters of diastolic function.

Summary:

  • Doppler echocardiography in 45 normal subjects revealed age-related changes in atrioventricular blood flow.
  • Key findings include increased amplitude and velocity time integral (VTI) of A waves and decreased E wave amplitude and VTI.
  • An increased left ventricular isovolumic relaxation period was observed with age.

Impact:

  • The study highlights age-related shifts in diastolic function parameters, affecting the E/A wave ratios.
  • It emphasizes the utility of the E wave VTI/total VTI ratio, which is independent of sample volume position.
  • Demonstrates an age-related decrease in this ratio, providing a more robust indicator of diastolic changes.

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