Related Experiment Video
Updated: Sep 12, 2026

Femoral Arterial and Venous Catheterization for Blood Sampling, Drug Administration and Conscious Blood Pressure and Heart Rate Measurements
Published on: January 24, 2012
[The humeral artery and clinical pharmacology]
1Service de pharmacologie clinique, hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Abstract:
Regional haemodynamic parameters such as blood flow, brachial artery diameter and forearm resistances may be measured or calculated non-invasively by pulsed Doppler techniques, and, in the absence of blood pressure changes, provide a method of observing and quantifying the vasomotor tone of small or large arteries. This type of study therefore allows characterisation of the vascular effects of drugs whether they be vasodilators or substances with a preferential mode of action on the myocardium. These effects can be situated with respect to the central hemodynamics in order to determine the presence of phenomena of regional redistribution of cardiac output, the regional vascular changes observed after taking a meal or in cardiac failure, with and without treatment; this should lead to a better understanding of the mode of action of drugs used in cardiovascular disease and also of the underlying physiopathological mechanisms.
Related Concept Videos
Arteries of the Head and Neck
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
Arteries of the Upper Limbs
Drug Binding to Blood Components
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are further...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Hypertension III: Clinical Manifestations and Diagnostic Studies
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

