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Updated: Jun 6, 2026

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
10:41

Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound

Published on: June 3, 2021

Mitogen-activated protein kinases in cerebral vasospasm after subarachnoid hemorrhage: a review

Hidenori Suzuki1, Yu Hasegawa, Kenji Kanamaru

  • 1Department of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA 92354, USA.

Acta Neurochirurgica. Supplement
|December 1, 2010
PubMed
Abstract

Insights

Mitogen-activated protein kinases (MAPKs) play a key role in cerebral vasospasm after subarachnoid hemorrhage. Inhibiting MAPKs effectively prevents vasospasm, highlighting their therapeutic potential.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Mitogen-activated protein kinases (MAPKs) are implicated in cerebral vasospasm following subarachnoid hemorrhage.
  • Understanding MAPK pathways is crucial for addressing post-hemorrhage complications.

Purpose of the Study:

  • To review and synthesize current research on the role of MAPKs in cerebral vasospasm.
  • To identify knowledge gaps and suggest future research directions.

Main Methods:

  • Comprehensive literature search of PubMed and NIH databases (August 2009).
  • Keywords: subarachnoid hemorrhage, mitogen-activated protein kinases (MAPKs).
  • Inclusion of in vitro and in vivo studies.

Main Results:

  • MAPK inhibition, using specific inhibitors, demonstrated a preventative effect on vasospasm in most studies.
  • MAPK cascades appear to be a central signaling pathway in cerebral vasospasm.
  • The precise mechanism of MAPK-induced sustained vascular smooth muscle contraction requires further elucidation.
  • The role of endogenous MAPK inhibitors (MAPK phosphatases) in this context remains unexplored.

Conclusions:

  • Experimental evidence strongly supports a causative role for MAPKs in cerebral vasospasm.
  • Further investigation into MAPK signaling and its modulation is warranted for therapeutic development.

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