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Updated: Aug 7, 2026

Evaluation of Mammary Gland Development and Function in Mouse Models
Published on: July 21, 2011
A mammary stimulating mitogen(s) from rat muscle: its possible influence in mammary tumorigenesis
1Biological Chemistry Division, Tata Memorial Centre, Parel, Bombay, India.
Abstract:
A mitogen has been shown to be present in rat abdominal muscle tissue, which could stimulate rat mammary cells grown in culture. Studies on the in vivo-stimulatory effects on the rat mammary gland, taking increase in DNA synthesis, mitotic index and wholemount preparation as the parameters, affirmed the presence of a mammary stimulating factor in the muscle tissue. Treatment of rat mammary glands with the crude mitogen preparation before and after a single gastric dose of 9,10-dimethyl-1,2-benzanthracene (DMBA), increased the mammary tumor incidence suggesting its possible influence in carcinogen-induced tumorigenesis in rats.
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