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Related Concept Videos

Structural Isomerism02:34

Structural Isomerism

Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can be...
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Colors and Magnetism03:02

Colors and Magnetism

Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human eye.
The Supercomplexes in the Crista Membrane01:41

The Supercomplexes in the Crista Membrane

The mitochondrial cristae membrane is the primary site for the oxidative phosphorylation (OXPHOS) process of energy conversion mediated through respiratory complexes I to V. These complexes have been widely studied for decades, and it has been proven that they form supramolecular structures called respiratory supercomplexes (SC). These higher-order complexes may be crucial in maintaining the biochemical structure and improving the physiological activity of the individual complexes while...
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...

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Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
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[Dinitrosyl iron complexes--structure and biological functions].

Hanna Lewandowska1, Kamil Brzóska, Sylwia Meczyńska-Wielgosz

  • 1Center of Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, 16 Dorodna St., 03-195 Warszawa, Poland.

Postepy Biochemii
|December 2, 2010
PubMed
Summary

Dinitrosyl iron complexes (DNICs) are found in biological systems during inflammation, ischemia, and cancer. These complexes may act as nitric oxide transducers, influencing cellular redox potential and vasodilation.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Physiology

Context:

  • Dinitrosyl iron complexes (DNICs) are observed in various organisms under conditions like inflammation, ischemia/reperfusion, and cancer.
  • DNIC formation correlates with increased nitric oxide (NO) production in diverse cell types, including macrophages, neurons, and hepatocytes.
  • Low-molecular weight thiol-containing DNICs (DNIC-(RS)2) exhibit vasodilatory effects.

Purpose:

  • To explore the role and characteristics of dinitrosyl iron complexes in biological systems.
  • To investigate the proposed function of DNICs as nitric oxide transducers and stabilizers.
  • To understand how DNICs modulate cellular redox potential through enzyme inhibition.

Summary:

  • DNICs, with the general formula Fe(NO)2(L)2, are implicated in physiological processes and diseases.
  • These complexes influence cellular redox balance by inhibiting glutathione-dependent enzymes.
  • While evidence suggests NO and NO+ donation, the precise nature, stability, and biological significance of DNICs remain under investigation.

Impact:

  • DNICs may serve as critical mediators in cellular signaling pathways related to NO.
  • Understanding DNICs could offer insights into therapeutic strategies for inflammatory and ischemic conditions.
  • Further research is needed to elucidate the complete biological role and stability of these iron-nitrosyl species.