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Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

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Related Experiment Video

Updated: Jun 6, 2026

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

Acute severe visual decrease after photodynamic therapy with verteporfin: spectral-domain OCT features.

Pearse A Keane¹, Elda Aghaian, Yanling Ouyang

¹Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033, USA.

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye

|December 2, 2010

Summary

This summary is machine-generated.

Spectral-domain optical coherence tomography (OCT) visualized distinct subretinal fluid compartments after photodynamic therapy, aiding in understanding severe vision decrease. This imaging technique improves evaluation of macular disease complications.

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Last Updated: Jun 6, 2026

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Published on: January 13, 2023

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Published on: May 26, 2023

Area of Science:

Ophthalmology
Medical Imaging

Background:

Photodynamic therapy (PDT) with verteporfin can cause acute severe visual decrease.
Neovascular age-related macular degeneration (nAMD) is a common cause of vision loss.

Observation:

Spectral-domain optical coherence tomography (SD-OCT) was used to examine a patient experiencing vision loss post-PDT.
Two distinct subretinal fluid compartments were identified using SD-OCT.

Findings:

A sparsely hyperreflective subretinal fluid pocket consistent with fibrinous exudation was observed.
A homogeneously hyporeflective peripheral compartment, indicative of serous exudation, was also visualized.
SD-OCT's high axial resolution enhanced visualization of subretinal fluid and macular disease.

Implications:

SD-OCT provides detailed morphologic characterization of acute complications following PDT.
Improved visualization of subretinal fluid may lead to new parameters for evaluating macular disease.
This imaging modality enhances understanding of vision loss mechanisms in nAMD patients undergoing treatment.