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Vascular endothelial growth factor +936 C/T gene polymorphism and glioma risk in a Chinese Han population
Gang Bao1, Maode Wang, Shiwen Guo
1Department of Neurosurgery, The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, China. gangbao73@hotmail.com
Background:
Angiogenesis plays an important role in tumor progression. The vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis.
Aim:
The objective of this study was to investigate the association between VEGF +936 C/T gene polymorphism and glioma risk in a Chinese Han population.
Methods:
We extracted the peripheral blood samples in 160 glioma patients and 320 controls. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism method.
Results:
Glioma patients had a significantly higher frequency of TT genotype (odds ratio [OR] = 3.75, 95% confidence interval [CI] = 1.24, 11.40; p = 0.02) than controls. Glioblastoma patients had a significantly higher frequency of TT genotype (OR = 3.05, 95% CI = 1.11, 8.37; p = 0.03) than other gliomas. Patients with grade IV glioma had a significantly higher frequency of TT genotype (OR = 3.12, 95% CI = 1.14, 8.58; p = 0.03) than low-grade glioma.
Conclusion:
Our study indicated that VEGF + 936 C/T genotype was associated with a higher glioma risk in a Chinese Han population.
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