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Endolysosomal calcium regulation and disease

Emyr Lloyd-Evans1, Helen Waller-Evans, Ksenia Peterneva

  • 1Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. lloyd-evanse@cardiff.ac.uk

Biochemical Society Transactions
|December 2, 2010
PubMed
Summary

Endolysosomal calcium regulation is crucial for cellular function. This review explores how disruptions in calcium release mechanisms, particularly involving nicotinic acid-adenine dinucleotide phosphate (NAADP), contribute to metabolic disorders like Niemann-Pick type C.

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