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Related Concept Videos

Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

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Related Experiment Video

Updated: Jun 6, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Dermatomyositis related to autoimmune thyroiditis.

H Wang1, L Tao, H Li

  • 1Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Journal of the European Academy of Dermatology and Venereology : JEADV
|December 2, 2010
PubMed
Summary

Dermatomyositis (DM) and autoimmune thyroiditis (AIT) can coexist, primarily affecting women. Routine thyroid function tests and comorbidity screening are recommended for DM patients with AIT, with combined corticosteroid and levothyroxine treatment showing potential utility.

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

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Last Updated: Jun 6, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Area of Science:

  • Rheumatology
  • Endocrinology
  • Autoimmune Diseases

Background:

  • Dermatomyositis (DM) and autoimmune thyroiditis (AIT) are distinct autoimmune conditions.
  • Coexistence of DM and AIT is infrequently reported, necessitating further investigation into their relationship.

Purpose of the Study:

  • To define the relationship between coexisting DM and AIT.
  • To identify the clinical, laboratory, electromyographic, and pathological features of patients with both DM and AIT.

Main Methods:

  • A systematic MEDLINE search was conducted for literature published in the last 30 years.
  • Retrospective analysis of medical records from five patients diagnosed with both DM and AIT.

Main Results:

  • Eleven cases were analyzed, predominantly affecting females (90.9%).
  • Common comorbidities included hypothyroidism (90.9%) and cardiopulmonary diseases (63.7%).
  • Muscle weakness (100%), polyarthralgia (45.5%), and heliotrope rash (45.5%) were the most frequent clinical manifestations.

Conclusions:

  • Malignancy prevalence appears low in coexistent DM and AIT.
  • Routine thyroid function evaluation and comorbidity screening are advised for DM patients with AIT.
  • Combined corticosteroid and levothyroxine therapy may be a beneficial standard treatment approach.