Fasting serum leptin level correlates with mid-arm fat area in peritoneal dialysis patients

Leptin correlates with body fat content and plays a pivotal role in inflammatory response. This study aimed to investigate the relationships of fasting serum leptin levels and the anthropometric fat components among peritoneal dialysis (PD) patients. Fasting blood samples were obtained from 40 PD patients. Leptin levels were measured using a commercial enzyme-linked immunosorbent assay kit. Body weight (r=0.424; P=0.006), waist circumference (r=0.352; P=0.026), body mass index (BMI; r=0.483; P=0.002), body fat mass (r=0.352; P=0.026), high sensitivity C-reactive protein (hs-CRP; r=0.494; P=0.001), triceps skinfold thickness (TSF; r=0.505; P=0.001), mid-arm circumference (MAC; r=0.471; P=0.002), and mid-arm fat area (MAFA; r=0.564; P<0.001) were positively correlated, while high density lipoprotein (HDL)-cholesterol (r=-0.345; P=0.028) was negatively correlated with fasting serum leptin levels among the PD patients. Multivariate forward stepwise linear regression analysis showed that MAFA (R(2)=0.318, P=0.011) was the independent predictor of fasting serum leptin levels among the PD patients. In conclusion, fasting leptin level was positively associated with body fat composition (body weight, waist circumference, BMI, body fat mass, TSF, MAC, and MAFA) and hs-CRP among PD patients, and MAFA was the independent predictor of fasting serum leptin levels among the PD patients.