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Determinants of masked hypertension in hypertensive patients treated in a primary care setting
A Andalib1, S Akhtari, R Rigal
1Montreal Heart Institute Coordinating Centre (MHICC), Montreal, Quebec, Canada.
Insights
Masked hypertension (MH), where home blood pressure is high but office readings are normal, affects nearly one in five hypertensive patients. This condition is linked to cardiovascular risks and other factors like diabetes and obesity.
Area of Science:
- Cardiology
- Hypertension Management
- Primary Care Research
Background:
- Masked hypertension (MH) presents cardiovascular risks comparable to uncontrolled hypertension.
- Understanding MH prevalence is crucial for effective hypertension management.
Purpose of the Study:
- To determine the prevalence and identify factors associated with masked hypertension (MH).
- Study conducted in a Canadian primary care setting among patients treated for hypertension.
Main Methods:
- 5636 hypertensive patients underwent office blood pressure (OBP) and home blood pressure monitoring (HBPM) measurements.
- MH defined by specific OBP and HBPM thresholds, differing for diabetic and non-diabetic patients.
Main Results:
- Overall, 19.6% of the study population had MH.
- MH was found in 34.3% of non-diabetic patients and 62.3% of diabetic patients with controlled OBP.
- In non-diabetics with controlled OBP, MH determinants included older age, male sex, higher BMI, and higher OBP.
Conclusions:
- Masked hypertension (MH) affects a significant portion of hypertensive patients, particularly those with controlled office blood pressure.
- MH is associated with cardiovascular risk factors including diabetes, male sex, older age, and obesity.
Background:
Recent data suggest that masked hypertension (MH) carries a cardiovascular risk similar to that of uncontrolled hypertension.
Aims:
The objective of this study was to determine the prevalence and determinants of MH in patients treated for hypertension in a Canadian primary care setting.
Methods:
Office blood pressure (OBP) was measured at baseline and after 3 months of valsartan-based therapy in 5636 hypertensive patients who had recorded their home blood pressure monitoring (HBPM) for seven consecutive days at month 3 using an Omron HEM-711 apparatus. MH was defined in nondiabetic patients as an OBP <140/90 mmHg and an HBPM ≥135/85 mmHg, and in those with diabetes as an OBP <130/80 mmHg and an HBPM ≥125/75 mmHg.
Results:
Of the 5636 patients, 1025 had diabetes. OBP was controlled at 3 months in 268 (26.1%) of them, but 167 (62.3%) had MH. OBP was controlled in 2728 (59.1%) of the 4611 patients without diabetes, and 935 (34.3%) of them had MH. Overall, 1102 patients had MH, representing 36.8% of patients with controlled OBP and 19.6% of the entire hypertensive study population. Stepwise multiple logistic regression analysis in nondiabetic patients with controlled OBP at 3 months revealed that older age, male sex, higher body mass index and higher office systolic blood pressure were determinants of MH.
Conclusion:
Our results indicate that one of five hypertensive patients and more than one of three with controlled OBP will have MH. MH is associated with other cardiovascular risk factors, such as diabetes, and in nondiabetics, with male sex, older age and obesity.
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