Systemic panca-associated vasculitis with central nervous involvement causing recurrent myelitis: case report
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Updated: Jun 6, 2026

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis
Published on: February 23, 2024
Alexander J Hamilton1, Duncan J Whitehead, Matthew D Bull
1Exeter Kidney Unit, Royal Devon and Exeter NHS Foundation Trust, Barrack Road, Exeter, Devon, EX2 5DW, UK. alexander.hamilton@nhs.net
Background:
We report on the case of an established perinuclear antineutrophil cytoplasmic antibody (pANCA) associated renal vasculitis being treated with prednisolone and rituximab, where the patient presented with leg weakness, urinary and faecal incontinence and buttock pain consistent with transverse myelitis.
Case Presentation:
The patient underwent MRI scanning showing patchy cord enhancement from T10 to the conus, which was suggestive of a cord malignancy. Prior to a cord biopsy, he was treated with steroids and a repeat MRI showed resolution of the original lesion with a new similar lesion from C7 to T3.
Conclusions:
He made a marked recovery after further treatment with high dose steroids and plasma exchange.
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