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Updated: Jun 6, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
[Cerebral manifestations of influenza A (H1N1)v]
Pia Sønderby Christensen1, Birgitte Bang Pedersen, Helga Gulisano
1Børneafdelingen, Århus Universitets hospital, Aalborg Sygehus, Denmark. pias@dadlnet.dk
Insights
Influenza A (H1N1)v can cause severe neurological issues, including cerebral edema and encephalitis. Prompt medical intervention, such as decompressive craniectomy, may be crucial for patient recovery.
Area of Science:
- Neurology
- Infectious Diseases
- Critical Care Medicine
Background:
- Influenza A (H1N1)v, a novel influenza A virus, emerged in 2009.
- Neurological complications associated with influenza are rare but can be severe.
Observation:
- Two cases of cerebral manifestations in patients with influenza A (H1N1)v infection are presented.
- Case 1: A 13-year-old boy with severe cerebral edema and increased intracranial pressure, treated with decompressive craniectomy.
- Case 2: A 25-year-old man with encephalopathy and convulsions, diagnosed with encephalitis via MRI.
Findings:
- Influenza A (H1N1)v infection can lead to serious neurological complications.
- Decompressive craniectomy was effective in managing severe cerebral edema.
- Complete recovery was observed in both patients following appropriate medical and surgical interventions.
Implications:
- Highlights the potential for life-threatening neurological sequelae of influenza A (H1N1)v.
- Emphasizes the importance of recognizing and managing neurological complications in influenza patients.
- Suggests that aggressive management strategies may improve outcomes in severe cases.
Abstract:
We describe two patients with cerebral manifestations of influenza A (H1N1)v. A 13-year-old boy developed severe cerebral oedema and increased intracranial pressure despite medical treatment and external drainage of cerebrospinal fluid. He was treated with bifrontal decompressive craniectomy with good result. A 25-year-old man with a previous kidney transplant developed encephalopathy and convulsions. Magnetic resonance imaging showed encephalitis. The patient fully recovered. The cases demonstrate that influenza A (H1N1)v can cause seriously and potentially life-threatening neurological complications.
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