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Related Experiment Video

Updated: Jun 6, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Baclofen-induced morbiliform rashes: a case series.

Sahoo Saddichha, Naveen Jayaram, Narayana Manjunatha

    Journal of Clinical Pharmacology
    |December 2, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Baclofen, a GABA derivative, can rarely cause morbiliform rashes. This case series reports four patients experiencing this exceedingly rare adverse effect after starting baclofen treatment.

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    Last Updated: Jun 6, 2026

    A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
    07:50

    A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

    Published on: September 20, 2018

    Area of Science:

    • Pharmacology
    • Dermatology
    • Addiction Medicine

    Background:

    • Baclofen, a gamma-aminobutyric acid (GABA) derivative, is a GABA-B receptor agonist.
    • Initially indicated for spasticity, it is now explored for alcohol dependence treatment.
    • Adverse effects of baclofen are known, but cutaneous reactions are uncommon.

    Observation:

    • This study presents a case series of four patients.
    • All patients developed morbiliform rashes following the initiation of baclofen therapy.
    • Morbiliform rash is an exceedingly rare adverse effect of baclofen, with only one prior report.

    Findings:

    • Baclofen use was associated with the development of morbiliform rashes in four patients.
    • This observation expands the known spectrum of rare adverse cutaneous reactions to baclofen.
    • The incidence of morbiliform rashes, though rare, warrants clinical consideration.

    Implications:

    • Clinicians should be aware of the potential for morbiliform rashes in patients prescribed baclofen.
    • Early recognition and management of baclofen-induced rashes are crucial.
    • Further research may elucidate the mechanisms underlying this rare adverse event.