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Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Updated: Jun 6, 2026

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

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Published on: August 8, 2020

Sprayed cultured mucosal epithelial cell for deep dermal burns.

Minoru Ueda1

  • 1Department of Oral and Maxillofacial Surgery, School of Medicine, Nagoya University, Nagoya, Japan. mueda@med.nagoya-u.ac.jp

The Journal of Craniofacial Surgery
|December 2, 2010
PubMed
Summary

Cultured mucosal epithelial autograft (CMEA) suspensions sprayed onto deep dermal burns promote rapid healing and excellent cosmetic outcomes. This innovative technique offers a promising alternative for burn wound management.

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Area of Science:

  • Regenerative Medicine
  • Wound Healing
  • Dermatology

Background:

  • Mucosal epithelial cells offer advantages over epidermal cells, including superior proliferation and biologic activity.
  • Deep dermal burns present significant challenges in wound healing and scar management.

Purpose of the Study:

  • To evaluate the clinical efficacy of sprayed cultured mucosal epithelial autograft (CMEA) suspensions for treating deep dermal burn wounds.
  • To assess the cosmetic and healing outcomes of CMEA application in burn patients.

Main Methods:

  • A prospective study involving ten patients with deep dermal burns.
  • Application of CMEA suspension via a spray technique onto burn wounds after enzymatic and surgical debridement.
  • Clinical follow-up of eight patients for an average of 10 months, assessing scar quality and epithelialization time.

Main Results:

  • Average Vancouver Scar Scale score of 1.5 points at follow-up, indicating excellent cosmetic results.
  • Average epithelialization period of 12.5 days.
  • Successful treatment of deep dermal burns with minimal scarring.

Conclusions:

  • Sprayed CMEA suspension is an effective method for treating deep dermal burns.
  • The technique yields excellent cosmetic outcomes and promotes rapid wound healing.
  • CMEA offers a superior alternative to existing burn wound treatment methods.